Endocrine Abstracts

Introduction:Vascular endothelial growth factor (VEGF), a potent angiogenic growth factor, has been implicated in various disease states, particularly pre-eclampsia. VEGF exerts its biological activities through two different receptor tyrosine kinases: KDR and Flt-1. Alternative splicing of Flt-1 pre-mRNA produces two products, one encoding the full-length receptor and the other a soluble form, sFlt-1. As sFlt-1 inhibits VEGF activities the regulation of...